Harris, Frederick, Dennison, Sarah Rachel and Phoenix, David A. (2014) Sounding the death knell for microbes? Trends in Molecular Medicine, 20 (7). pp. 363-367.
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Official URL: http://dx.doi.org/10.1016/j.molmed.2014.05.005
Over the past 5 years, several studies showed that ultrasound, which is sound with a frequency>20 kHz, is able to kill bacteria by activating molecules termed sonosensitizers (SS) to produce reactive oxygen species, which are toxic to microbes. It is our opinion that this work opens up the potential for the development of a novel form of ultrasound-mediated antimicrobial therapy. Termed sonodynamic antimicrobial chemotherapy (SACT), we define this therapy as a regime where a SS is selectively delivered to target microbial cells and activated by ultrasound to induce the death of those microbial cells. Here, we review recent work on SACT, current understanding of its mechanisms, and future prospects for SACT as a therapeutically viable antimicrobial regime.
|Subjects:||C - Biological sciences > C100 - Biology|
C - Biological sciences > C500 - Microbiology
|Schools:||Faculty of Clinical & Biomedical Sciences > School of Pharmacy and Biomedical Sciences|
|Deposited By:||Sarah Rachel Dennison|
|Deposited On:||28 May 2015 12:43|
|Last Modified:||09 Aug 2016 15:22|
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