Snape, Timothy J. and Warr, Tracy (2014) Approaches Toward Improving the Prognosis of Pediatric Patients With Glioma: Pursuing Mutant Drug Targets With Emerging Small Molecules. Seminars in Pediatric Neurology, 22 (1). pp. 28-34.
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Official URL: http://dx.doi.org/10.1016/j.spen.2014.12.003
Gliomas represent approximately 70% of all pediatric brain tumors and most of these are of astrocytic lineage, furthermore, malignant or high-grade astrocytoma account for approximately 20% of pediatric astrocytoma. Treatment options for pediatric glioma patients are limited. Although low-grade astrocytoma are relatively slow-growing tumors which can often be cured through surgical resection, a significant proportion of cases will recur, as such new treatments are desperately needed. This review covers the various approaches that are currently being made towards improving the prognosis of pediatric glioma patients by pursuing pediatric-selective mutant drug targets with emerging small molecules.
|Subjects:||Physical sciences > Chemistry|
|Schools:||Faculty of Clinical & Biomedical Sciences > School of Pharmacy and Biomedical Sciences|
|Deposited By:||Timothy James Snape|
|Deposited On:||03 Sep 2015 12:45|
|Last Modified:||21 Apr 2017 07:22|
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