A facile approach to manufacturing non-ionic surfactant nanodipsersions using proniosome technology and high-pressure homogenization

Najlah, Mohammad, Hidayat, Kanar, Omer, Huner K., Mwesigwa, Enosh, Ahmed, Waqar orcid iconORCID: 0000-0003-4152-5172, AlObaidy, Kais G., Phoenix, David Andrew and Elhissi, Abdelbary (2014) A facile approach to manufacturing non-ionic surfactant nanodipsersions using proniosome technology and high-pressure homogenization. Journal of Liposome Research, 25 (1). pp. 32-37. ISSN 0898-2104

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Official URL: http://dx.doi.org/10.3109/08982104.2014.924140

Abstract

In this study, a niosome nanodispersion was manufactured using high-pressure homogenization following the hydration of proniosomes. Using beclometasone dipropionate (BDP) as a model drug, the characteristics of the homogenized niosomes were compared with vesicles prepared via the conventional approach of probe-sonication. Particle size, zeta potential, and the drug entrapment efficiency were similar for both size reduction mechanisms. However,
high-pressure homogenization was much more efficient than sonication in terms of homogenization output rate, avoidance of sample contamination, offering a greater potential for a large-scale manufacturing of noisome nanodispersions. For example, high-pressure homogenization was capable of producing small size niosomes (209 nm) using a short singlestep of size reduction (6 min) as compared with the time-consuming process of sonication (237nm in 418 min) and the BDP entrapment efficiency was 29.65% ± 4.04 and 36.4% ± 2.8.
In addition, for homogenization, the output rate of the high-pressure homogenization was 10 ml/min compared with 0.83 ml/min using the sonication protocol. In conclusion, a facile, applicable, and highly efficient approach for preparing niosome nanodispersions has been
established using proniosome technology and high-pressure homogenization.


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