Shrestha, Badri and Haylor, John (2014) Experimental rat models of chronic allograft nephropathy: a review. International Journal of Nephrology and Renovascular Disease, 7 . pp. 315-322. ISSN 1178-7058
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Official URL: http://dx.doi.org/10.2147/IJNRD.S65604
Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT can be technically challenging, it is attractive because the pathogenesis of CAN is similar to that following human RT and the pathological features of CAN develop within months as compared with years in human RT. The rat model of RT is considered as a useful investigational tool in the field of experimental transplantation research. We have reviewed the literature on studies of rat RT reporting the donor and recipient strain combinations that have investigated resultant survival and histological outcomes. Several different combinations of inbred and outbred rat combinations have been reported to investigate the multiple aspects of transplantation, including acute rejection, cellular and humoral rejection mechanisms and their treatments, CAN, and potential targets for its prevention.
|Uncontrolled Keywords (separate with ;):||interventions; therapy; late allograft loss; renal transplantation|
|Schools:||Faculty of Clinical & Biomedical Sciences > School of Medicine|
|Deposited By:||Helen Cooper|
|Deposited On:||28 Jan 2016 17:53|
|Last Modified:||19 Oct 2016 13:15|
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