Songkro, S, Rades, T and Becket, Gordon (2009) Effects of some terpenes on the in-vitro permeation of LHRH through newborn pig skin. Pharmazie: an international journal of pharmaceutical sciences, 64 (2). pp. 110-115. ISSN 0031-7144
Full text not available from this repository.
Official URL: http://www.ingentaconnect.com/content/govi/pharmaz...
The objective of this work was to investigate the effect of oxygen containing terpenes (carvacrol, menthol and carvone) at 5%w/v in hydroalcoholic mixtures (40% ethanol) on the permeation of LHRH across newborn pig skin in vitro. In addition, the amount of LHRH retained in the skin after 24 h of diffusion was determined. It was found that the passive permeation of LHRH was very limited. Although percutaneous absorption of LHRH improved in the presence of the enhancers, a significant enhancement was observed only with carvacrol, an aromatic terpene. The rank order of enhancement ratio for skin permeation was found to be carvacrol > carvone > menthol. The enhancers also affected the retention of LHRH in the skin. The rank order of enhancement ratio for skin retention was carvone > carvacrol > menthol. The results of the in vitro skin metabolism study of LHRH using fresh newborn pig skin showed that the degradation products were detected and the amount of the degraded LHRH increased with increasing duration of incubation time.
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Schools:||College of Clinical & Biomedical Sciences > School of Pharmacy and Biomedical Sciences|
|Deposited By:||Helen Cooper|
|Deposited On:||06 Aug 2010 16:33|
|Last Modified:||21 Feb 2013 17:56|
Downloads per month over past year
Downloads for past 30 days
Repository Staff Only: item control page