A truce on the Smiles rearrangement: revisiting an old reaction—the Truce–Smiles rearrangement

Abstract

The Smiles rearrangement is the intramolecular nucleophilic aromatic substitution reaction incorporating a heteroatom as the nucleophilic component and an activated electrophilic arene. One particular variation—the Truce–Smiles rearrangement—utilises a carbon-based nucleophile and an electrophilic arene which does not require additional activation. Such a variation generates a new carbon–carbon bond and the synthetic utility of this relatively under-utilised rearrangement is discussed in this tutorial review.