Gold nanoparticles as a substrate in bio-analytical near-infrared surface-enhanced Raman spectroscopy

Butler, Holly J., Fogarty, Simon W., Kerns, Jemma G., Martin-Hirsch, Pierre L., Fullwood, Nigel J. and Martin, Francis L orcid iconORCID: 0000-0001-8562-4944 (2015) Gold nanoparticles as a substrate in bio-analytical near-infrared surface-enhanced Raman spectroscopy. Analyst, 140 (9). pp. 3090-3097. ISSN 0003-2654

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Official URL: http://dx.doi.org/10.1039/c4an01899k

Abstract

As biospectroscopy techniques continue to be developed for screening or diagnosis within a point-ofcare setting, an important development for this field will be high-throughput optimization. For many of these techniques, it is therefore necessary to adapt and develop parameters to generate a robust yet simple approach delivering high-quality spectra from biological samples. Specifically, this is important for surface-enhanced Raman spectroscopy (SERS) wherein there are multiple variables that can be optimised to achieve an enhancement of the Raman signal from a sample. One hypothesis is that "large" diameter (>100 nm) gold nanoparticles provide a greater enhancement at near-infrared (NIR) and infrared (IR) wavelengths than those


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