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Sonnenschein, Eva C., Stierhof, Marc, Goralczyk, Stephan, Vabre, Floriane M., Pellissier, Leonie, Hanssen, Kine Østnes, de la Cruz, Mercedes, Díaz, Caridad, de Witte, Peter , Copmans, Daniëlle, Andersen, Jeanette Hammer, Hansen, Espen, Kristoffersen, Venke, Tormo, José R., Ebel, Rainer, Milne, Bruce F., Deng, Hai, Gram, Lone, Jaspars, Marcel and Tabudravu, Jioji 
ORCID: 0000-0002-6930-6572 (hide)
(2017)
Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040.
Tetrahedron, 73
(18).
pp. 2633-2637.
ISSN 0040-4020
|
PDF (Author Accepted Manuscript)
- Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. 924kB |
Official URL: https://doi.org/10.1016/j.tet.2017.03.051
Abstract
A new siderophore containing a 4,5-dihydroimidazole moiety was isolated from Pseudoalteromonas piscicida S2040 together with myxochelins A and B, alteramide A and its cycloaddition product, and bromo- and dibromoalterochromides. The structure of pseudochelin A was established by spectroscopic techniques including 2D NMR and MS/MS fragmentation data. In bioassays selected fractions of the crude extract of S2040 inhibited the opportunistic pathogen Pseudomonas aeruginosa. Pseudochelin A displayed siderophore activity in the chrome azurol S assay at concentrations higher than 50 μM, and showed weak activity against the fungus Aspergillus fumigatus, but did not display antibacterial, anti-inflammatory or anticonvulsant activity.
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