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Phages Enter the Fight against Colorectal Cancer

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Kannen, Vinicius, Parry, Lee and Martin, Francis L ORCID: 0000-0001-8562-4944 (2019) Phages Enter the Fight against Colorectal Cancer. Trends in Cancer, 5 (10). pp. 577-579.

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Official URL: https://doi.org/10.1016/j.trecan.2019.08.002

Abstract

Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC. [Abstract copyright: Copyright © 2019 Elsevier Inc. All rights reserved.]

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CORE (COnnecting REpositories)