Alumni
As a member of our Alumni Network, you are always part of the University of Central Lancashire.
Business and Enterprise
We have a strong reputation for applied business research, entrepreneurship and innovation, offering a wide range of specialist business support.
News
Read the the latest news and updates from across the University.
Work here
Discover more about working at one of England’s largest universities in the heart of the North West. Find out more about working at UCLan and browse our latest job opportunities.
Events at UCLan and beyond
We host a wide variety of events open to the public. These include performances and exhibitions, public lectures, festivals and more...
Visit us
Find out more about great ways to visit our campus from Open Days to Academic conferences. There's something for everyone.

Research
We have a growing and vibrant community of academics producing high quality research.
Research Services
We provide a professional, effective and holistic offering for researchers, from ideas and training to funding, dissemination and governance.
Research Themes
Our research fits under six broad themes, ranging from arts and culture to transformative science and technology.
Research Centres
Our interdisciplinary Research Centres are the home of world-class research that brings together expertise from across the University enabling us to provide real-world solutions and opportunities that have an impact on society.
Postgraduate research degrees
We offer a vibrant and world-class research environment, matched by excellent facilities, comprehensive research support and award-winning training opportunities.

Business and Enterprise
We have a strong reputation for applied business research, entrepreneurship and innovation, offering a wide range of specialist business support.
Training and development
We work in partnership with organisations from all sectors to develop and deliver tailored training programmes.
Recruit our Students
Are you looking for someone to bring new ideas and a fresh approach to your business? A UCLan student or graduate could be just what you need.
Support for SMEs
Support and funding for small and medium sized businesses
Apprenticeships
Looking to sponsor or employ a degree apprentice? We offer a wide range of higher and degree apprenticeships.

International students
If you’re looking to study at a great university in the North West, the University of Central Lancashire is a great choice to start or continue your studies in the UK.
International
We are an international, multi-campus university leading the way in modern learning.

Welcome and arrival information
Everything you need to know about starting university
Student experience
For everything about University life, from sports clubs to join, to student support.
Campuses and partners
We have a large and diverse campus network, with campus locations in Preston, Burnley, Westlakes and Cyprus.
Student support
We're here for you, no matter what. We offer expert advice and support in key areas such as health and inclusion to financial matters, visas and more.
Accommodation
Our student accommodation options offer great value for money in a safe, vibrant and inclusive halls community.

Undergraduate study
As an undergraduate student, you’ll benefit from the perfect mix of academic study and a range of opportunities that will set you up for a lifetime of success.
Postgraduate study
Whether you’re looking to develop your knowledge, enhance your career or change direction completely, our postgraduate courses can support your goals.
Postgraduate research degrees
We offer a vibrant and world-class research environment, matched by excellent facilities, comprehensive research support and award-winning training opportunities.
Degree Apprenticeships
Earn your qualification in a paid position within a company or organisation.
Professional Development & Short Courses
We offer professional development for you or your team to help plug a skills gap, offer continuing professional development or support career progression.

To Breathe or Not to Breathe: The Role of Oxygen in Bone Marrow-Derived Mesenchymal Stromal Cell Senescence

Lists

Tools

Gala, Dhir Niren ORCID: 0000-0003-1410-8576 and Fabian, Zsolt ORCID: 0000-0002-4973-9872 (2021) To Breathe or Not to Breathe: The Role of Oxygen in Bone Marrow-Derived Mesenchymal Stromal Cell Senescence. Stem Cells International, 2021 . -10. ISSN 1687-966X

[thumbnail of Version of Record]

Preview

PDF (Version of Record) - Published Version
Available under License Creative Commons Attribution.
690kB

Official URL: https://doi.org/10.1155/2021/8899756

Abstract

Stem cell-based cellular therapy is a promising tool for the treatment of pathological conditions with underlying severe tissue damage or malfunction like in chronic cardiovascular, musculoskeletal, or inflammatory conditions. One of the biggest technical challenges of the use of natural stem cells, however, is the prevention of their premature senescence during therapeutical manipulations. Culturing stem cells under hypoxic conditions is believed to be a possible route to fulfill this goal. Here, we review current literature data on the effects of hypoxia on bone marrow-derived mesenchymal stromal cells, one of the most popular tools of practical cellular therapy, in the context of their senescence.

Repository Staff Only: item control page

Altmetric

Summary Table

CORE (COnnecting REpositories)

CORE (COnnecting REpositories)