Lowe, Nicola M, Mitra, Soma R., Foster, Peter C., Bhojani, Issak and McCann, John F. (2010) Vitamin D status and markers of bone turnover in Caucasian and South Asian postmenopausal women living in the UK. British Journal of Nutrition, 103 (12). pp. 1706-1710. ISSN 0007-1145
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Official URL: http://dx.doi.org/10.1017/S0007114509993850
Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its impact on bone health is unclear. The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. A cross-sectional study of community-dwelling women aged 50–66 years was carried out. A total of sixty-six SA women of Pakistani origin and forty-two C women living in the same community were recruited. Fasting blood was taken for the measurement of vitamin D, PTH and biochemical markers of bone turnover, including type-1 collagen b C-telopeptide (bCTX), procollagen type-1 amino-terminal propeptide (P1NP), and bone-specific alkaline phosphatase (BAP) activity. Bone quality was assessed using broadband ultrasound attenuation (BUA). Total serum 25-hydroxyvitamin D (25(OH)D) was significantly lower in the SA women than the C women (medians: SA 10•5 v. C 47•1 nmol/l; P,0•001) This was associated with a significantly elevated serum PTH concentration in the SA group (medians: SA 7•3 v. C 4•5 pmol/l; P,0•01). BAP activity was also significantly higher in the SA group, indicating elevated osteoblast activity and bone turnover (medians: SA 23•0 v. C 20•0 U/l; P,0•05). No significant differences were observed between the two groups for P1NP, bCTX or BUA. Although the SA women had significantly higher serum PTH and lower 25(OH)D concentrations than C women, this was not associated with significantly higher markers of bone resorption, or reduced bone quality in the SA women.
|Uncontrolled Keywords (separate with ;):||Vitamin D; Bone turnover; South Asian women|
|Subjects:||R Medicine > R Medicine (General)|
|Schools:||College of Health and Wellbeing > School of Sport Tourism & The Outdoors|
|Deposited By:||James Richards|
|Deposited On:||16 Mar 2012 19:07|
|Last Modified:||02 Dec 2013 14:54|
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