Calman, Lynn, Beaver, Kinta, Hind, Daniel, Lorigan, Paul, Roberts, Chris and Lloyd-Jones, Myfanwy (2011) Survival Benefits from Follow-Up of Patients with Lung Cancer. Journal of Thoracic Oncology, 6 (12). pp. 1993-2004. ISSN 1556-0864
Full text not available from this repository.
Official URL: http://www.ncbi.nlm.nih.gov/pubmed/21892108
The burden of lung cancer is high for patients and carers. Care after treatment may have the potential to impact on this. We reviewed the published literature on follow-up strategies intended to improve survival and quality of life.
We systematically reviewed studies comparing follow-up regimes in lung cancer. Primary outcomes were overall survival (comparing more intensive versus less intensive follow-up) and survival comparing symptomatic with asymptomatic recurrence. Quality of life was identified as a secondary outcome measure. Hazard ratios (HRs) and 95% confidence intervals from eligible studies were synthesized.
Nine studies that examined the role of more intensive follow-up for patients with lung cancer were included (eight observational studies and one randomized controlled trial). The studies of curative resection included patients with non-small cell lung cancer Stages I to III disease, and studies of palliative treatment follow-up included limited and extensive stage patients with small cell lung cancer. A total of 1669 patients were included in the studies. Follow-up programs were heterogeneous and multifaceted. A nonsignificant trend for intensive follow-up to improve survival was identified, for the curative intent treatment subgroup (HR: 0.83; 95% confidence interval: 0.66-1.05). Asymptomatic recurrence was associated with increased survival, which was statistically significant HR: 0.61 (0.50-0.74) (p < 0.01); quality of life was only assessed in one study.
This meta-analysis must be interpreted with caution due to the potential for bias in the included studies: observed benefit may be due to systematic differences in outcomes rather than intervention effects. Some benefit was noted from intensive follow-up strategies. More robust data, in the form of randomized controlled trials, are needed to confirm these findings as the review is based primarily on observational studies. Future research should also include patient-centered outcomes to investigate the impact of follow-up regimes on living with lung cancer and psychosocial well-being.
|Uncontrolled Keywords (separate with ;):||Lung cancer; Follow-up; Aftercare; Survival; Survivorship|
|Subjects:||R Medicine > R Medicine (General)|
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RT Nursing
|Schools:||College of Health and Wellbeing > School of Health Sciences|
|Deposited By:||Mehmood Kadir Mulla|
|Deposited On:||08 Mar 2012 16:02|
|Last Modified:||12 Jun 2012 11:00|
Downloads per month over past year
Downloads for past 30 days
Repository Staff Only: item control page