Thakkar, Dipti, Shervington, Leroy and Shervington, Amal (2011) Proteomic Studies Coupled with RNAi Methodologies can Shed Further Light on the Downstream Effects of Telomerase in Glioma. Cancer Investigation, 29 (2). pp. 113-122. ISSN 0735-7907
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Official URL: http://dx.doi.org/10.3109/07357907.2010.543212
A comprehensive proteomic study utilizing 2D-DIGE and MALDI-TOF was used to assess the effect of inhibiting two different regulatory mechanisms of telomerase in glioma. RNAi was used to target hTERT and hsp90α. Inhibition of telomerase activity resulted in downregulation of various cytoskeletal proteins with correlative evidence of the involvement of telomerase in regulating the expression of vimentin. Inhibition of telomerase via sihTERT resulted in the downregulation of vimentin expression in glioma cell lines in a grade-specific manner. This study identified novel downstream role of telomerase in regulating the expression of vimentin, thereby affecting tumor progression and metastasis.
|Uncontrolled Keywords (separate with ;):||Brain tumors; Cancer biomarkers; Gene expression; Molecular biology|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Schools:||College of Clinical & Biomedical Sciences > School of Pharmacy and Biomedical Sciences|
|Deposited By:||Jeannine Sullivan|
|Deposited On:||29 Mar 2012 19:28|
|Last Modified:||19 Jun 2012 14:19|
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