Johnston, G, Burton, D, Liley, F, Doyle, A, Murphy, M, Madden, G, Gdeisat, M, Moore, C, Marchant, T and Matuszewski, Bogdan J (2011) Analysis of microscopy and reconstructive images for applications in medicine and biology. In: Image Processing (ICIP), 2011 18th IEEE International Conference on. Institute of Electrical and Electronics Engineers (IEEE), Reston, VA, 3069 -3072. ISBN 978-1-4577-1304-0
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Official URL: http://dx.doi.org/10.1109/ICIP.2011.6116313
An investigation into orientation preferences shown by actin fibres within ex-situ actin as imaged by Atomic Force Microscopy (AFM) is described. Actin is a primary cytoskeletal component and is believed to play a vital role in cell structure. Actin structure images measured by AFM were analysed using automated pre-processing steps. These steps were identical for the production of an initial binary image, which was then processed by both Hough transformation and thinning. Results obtained question the validity of using the Hough transform approach, as bias could not easily be eliminated, and hence the Hough transform method was deemed to be unsuitable for this application and instead the thinning technique was used to identify and locate actin orientation within the AFM images. The results show that polymerised ex-situ actin fibres appears to display a bimodal distribution of orientation, with a 90 degree separation, with a significant co-efficient of bimodality of 0.656.
|Item Type:||Book Section|
|Uncontrolled Keywords (separate with ;):||Atomic force microscopy; feature extraction|
|Subjects:||Computer science > Computer architectures & operating systems|
Computer science > Software engineering
Engineering > Civil engineering
|Schools:||Faculty of Science and Technology > School of Engineering|
|Deposited By:||Bogdan Matuszewski|
|Deposited On:||09 Apr 2013 09:57|
|Last Modified:||17 May 2016 12:39|
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