Krysmann, M.J, Castelletto, V., McKendrick, J. E., Clifton, L. A., Harris, P. J. F. and King, S. M. (2008) Self-Assembly of Peptide Nanotubes in an Organic Solvent. Langmuir, 24 (15). pp. 8158-8162. ISSN 0743-7463
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Official URL: http://dx.doi.org/10.1021/la800942n
The self-assembly of a modified fragment of the amyloid β peptide, based on sequence Aβ(16-20), KLVFF, extended to give AAKLVFF is studied in methanol. Self-assembly into peptide nanotubes is observed, as confirmed by electron microscopy and small-angle X-ray scattering. The secondary structure of the peptide is probed by FTIR and circular dichroism, and UV/visible spectroscopy provides evidence for the important role of aromatic interactions between phenylalanine residues in driving β-sheet self-assembly. The β-sheets wrap helically to form the nanotubes, the nanotube wall comprising four wrapped β-sheets. At higher concentration, the peptide nanotubes form a nematic phase that exhibits spontaneous flow alignment as observed by small-angle neutron scattering.
|Uncontrolled Keywords (separate with ;):||Amines; Amino acids; Aromatic compounds; Circular dichroism spectroscopy; Concentration (process); Dichroism; Fourier transform infrared spectroscopy; Methanol; Nanopores; Nanostructured materials; Nanostructures; Nanotubes; Neutron scattering; Optical properties; Organic compounds; Organic solvents; Scattering; X ray scattering|
|Subjects:||B - Subjects allied to medicine > B200 - Pharmacology, toxicology & pharmacy|
B - Subjects allied to medicine > B230 - Pharmacy
|Schools:||Faculty of Science and Technology > School of Forensic and Applied Sciences|
|Deposited By:||Simone Finley|
|Deposited On:||10 Dec 2013 14:57|
|Last Modified:||15 Mar 2017 10:44|
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