Items where Author is "Leonidas, Demetres D."

Alexopoulos, Serafeim, Mcgawley, Megan, Mathews, Roshini Mariam, Papakostopoulou, Souzana, Koulas, Symeon, Leonidas, Demetres D., Zwain, Tamara, Hayes, Joseph ORCID: 0000-0002-7745-9616 and Skamnaki, Vasiliki (2024) Evidence for the Quercetin Binding Site of Glycogen Phosphorylase as a Target for Liver-Isoform-Selective Inhibitors against Glioblastoma: Investigation of Flavanols Epigallocatechin Gallate and Epigallocatechin. Journal of Agricultural and Food Chemistry, 72 (43). pp. 24070-24081. ISSN 0021-8561

Mathomes, Rachel Thelma ORCID: 0000-0002-1079-8509, Koulas, Symeon M., Tsialtas, Ioannis, Stravodimos, George, Welsby, Philip J., Psarra, Anna-Maria G., Stasik, Izabela ORCID: 0000-0002-7756-4731, Leonidas, Demetres D. and Hayes, Joseph ORCID: 0000-0002-7745-9616 (2023) Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its’ potential against glioblastoma in cellular models. Chemico-Biological Interactions, 382 . ISSN 0009-2797

Chetter, Ben, Kyriakis, Efthimios, Barr, Daniel, Karra, Aikaterini G., Katsidou, Elisabeth, Koulas, Symeon M., Skamnaki, Vassiliki T., Snape, Timothy James ORCID: 0000-0003-2766-4491, Psarra, Anna-Maria G. et al (2020) Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorganic Chemistry, 102 (104003). ISSN 0045-2068

Chatzileontiadou, Demetra S. M., Tsika, Aikaterini C., Diamantopoulou, Zoi, Delbé, Jean, Badet, Josette, Courty, José, Skamnaki, Vassiliki T., Parmenopoulou, Vanessa, Komiotis, Dimitri et al (2018) Evidence for Novel Action at the Cell-Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy and in silico and in vivo Studies. ChemMedChem, 13 (3). pp. 259-269. ISSN 1860-7179

Begum, Jaida, Skamnaki, Vassiliki T., Moffatt, Colin, Bischler, Nicolas, Sarrou, Josephine, Skaltsounis, Alexios-Leandros, Leonidas, Demetres D., Oikonomakos, Nikos G. and Hayes, Joseph ORCID: 0000-0002-7745-9616 (2015) An evaluation of indirubin analogues as phosphorylase kinase inhibitors. Journal of Molecular Graphics and Modelling, 61 . pp. 231-242. ISSN 10933263

Parmenopoulou, Vanessa, Kantsadi, Anastassia L., Tsirkone, Vicky G., Chatzileontiadou, Demetra S.M., Manta, Stella, Zographos, Spyros E., Molfeta, Christina, Archontis, Georgios, Agius, Loranne et al (2014) Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines. Bioorganic & Medicinal Chemistry, 22 (17). pp. 4810-4825. ISSN 0968-0896

Tsitsanou, Katerina E., Hayes, Joseph ORCID: 0000-0002-7745-9616, Keramioti, Maria, Mamais, Michalis, Oikonomakos, Nikos G., Kato, Atsushi, Leonidas, Demetres D. and Zographos, Spyros E. (2013) Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: Comparison of chrysin and flavopiridol. Food and Chemical Toxicology, 61 . pp. 14-27. ISSN 0278-6915

Manta, Stella, Xipnitou, Andromachi, Kiritsis, Christos, Kantsadi, Anastassia L., Hayes, Joseph ORCID: 0000-0002-7745-9616, Skamnaki, Vicky T., Lamprakis, Christos, Kontou, Maria, Zoumpoulakis, Panagiotis et al (2012) 3′-Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why. Chemical Biology & Drug Design, 79 (5). pp. 663-673. ISSN 17470277

Kantsadi, Anastasia L., Hayes, Joseph ORCID: 0000-0002-7745-9616, Manta, Stella, Skamnaki, Vicky T., Kiritsis, Christos, Psarra, Anna-Maria G., Koutsogiannis, Zissis, Dimopoulou, Athina, Theofanous, Stavroula et al (2012) The σ-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b. ChemMedChem, 7 (4). pp. 722-732. ISSN 18607179

Tsirkone, Vicky G., Tsoukala, Evangelia, Lamprakis, Christos, Manta, Stella, Hayes, Joseph ORCID: 0000-0002-7745-9616, Skamnaki, Vicky T., Drakou, Christina, Zographos, Spyros E., Komiotis, Dimitri et al (2010) 1-(3-Deoxy-3-fluoro-β-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies. Bioorganic & Medicinal Chemistry, 18 (10). pp. 3413-3425. ISSN 09680896

Hayes, Joseph ORCID: 0000-0002-7745-9616 and Leonidas, Demetres D. (2010) Computation as a tool for glycogen phosphorylase inhibitor design. Mini-Reviews in Medicinal Chemistry, 10 (12). pp. 1156-1174. ISSN 1389-5575

Dossi, Kyriaki, Tsirkone, Vicky G., Hayes, Joseph ORCID: 0000-0002-7745-9616, Matoušek, Josef, Poučková, Pavla, Souček, Josef, Zadinova, Marie, Zographos, Spyros E. and Leonidas, Demetres D. (2009) Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors. European Journal of Medicinal Chemistry, 44 (11). pp. 4496-4508. ISSN 02235234

Wen, Xiaoan, Sun, Hongbin, Liu, Jun, Cheng, Keguang, Zhang, Pu, Zhang, Liying, Hao, Jia, Zhang, Luyong, Ni, Peizhou et al (2008) Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies†. Journal of Medicinal Chemistry, 51 (12). pp. 3540-3554. ISSN 0022-2623