Preparation, Characterization and Cell Based Delivery of Stavudine Surface Modified Lipid Nanoparticles

Abstract

Previously it was shown that uncoated lipid nanoparticles of stavudine proved effective in targeting HIV viral sites in body. Therefore, the main objective of this work was to prepare and characterize surface modified stavudine entrapped lipid nanoparticles as potential drug delivery system for anti-HIV chemotherapy. The physical, targeting potential (both in vitro and in vivo) and toxicological evaluation was performed on developed nanocarriers. The degree of targeting and cellular uptake demonstrated differences among the surface coated
lipid nanoparticles. We found that developed lipid nanoparticles are easy to prepare using high pressure homogenization, and has excellent stability at room temperature and refrigeration condition. In future, developed surface modified lipid nanoparticles can be evaluated clinically.