A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions.

Lerner, Robin and Petritsch, Claudia (2014) A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. Nature Cell Biology, 16 (3). pp. 212-4.

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Official URL: http://dx.doi.org/10.1038/ncb2924

Abstract

Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.


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