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β2-Adrenergic receptor Gly16Arg polymorphism and impaired asthma control in corticosteroid-treated asthmatic adults.

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Manoharan, Arvind, Griffin, Benjamin, Lipworth, Joseph, Berg, Jonathan, Andrew, Nicola, Jackson, Catherine ORCID: 0000-0003-4266-2347 and Lipworth, Brian (2015) β2-Adrenergic receptor Gly16Arg polymorphism and impaired asthma control in corticosteroid-treated asthmatic adults. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 114 (5). pp. 421-423. ISSN 1081-1206

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Official URL: http://dx.doi.org/10.1016/j.anai.2015.01.017

Abstract

β2-Agonists are the most commonly prescribed asthma medication, and the β2-adrenergic receptor gene has been studied extensively. A single-nucleotide polymorphism causing the substitution of arginine (Arg) for glycine (Gly) at position 16 (Gly16Arg) of the β2-adrenergic receptor affects the response to β2-agonists. Regular exposure to β2-agonists results in down-regulation and uncoupling of β2-adrenoreceptors with associated subsensitivity or tachyphylaxis of response.1 Retrospective studies have reported an impaired therapeutic response in terms of peak expiratory flow in adults treated with long-acting β2-agonists (LABAs).

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