A rapid, chromatography-free route to substituted acridine–isoalloxazine conjugates under microwave irradiation

Johns, Stephen C., Crouch, Laurie L.E., Grieve, Stephen, Maloney, Holly L., Peczkowski, Gary R., Jones, Allison E., Sharp, Duncan and Smith, Robert B. orcid iconORCID: 0000-0002-2829-5360 (2014) A rapid, chromatography-free route to substituted acridine–isoalloxazine conjugates under microwave irradiation. Tetrahedron Letters, 55 (22). pp. 3308-3311. ISSN 00404039

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Official URL: http://dx.doi.org/10.1016/j.tetlet.2014.04.035

Abstract

Microwave irradiation was applied to a sequence of condensation reactions from readily available 9-chloroacridines to provide a range of novel acridine–isoalloxazine conjugates. The combination of these two moieties, both of biological interest, was achieved by a chromatography free route.


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