Apolipoprotein E related Co-Morbidities and Alzheimer’s disease

Singhrao, Simarjit Kaur orcid iconORCID: 0000-0001-9573-5963, Harding, Alice, Chukkapalli, Sasanka, Olsen, Ingar, Kesavalu, Lakshmyya and Crean, Stjohn orcid iconORCID: 0000-0001-9336-8549 (2016) Apolipoprotein E related Co-Morbidities and Alzheimer’s disease. Journal of Alzheimer’s Disease, 51 (4). pp. 935-948. ISSN 1387-2877

[thumbnail of Author Accepted Manuscript]
PDF (Author Accepted Manuscript) - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.


Official URL: http://dx.doi.org/10.3233/JAD150690


The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the population, have led to an increase in the worldwide challenge to the healthcare system. In order to overcome these challenges prior knowledge of common, reliable risk factors and their effectors is essential. The oral health constitutes one such relatively unexplored but indispensable risk factor for aforementioned co-morbidities, in the form of poor oral hygiene and tooth loss during aging. Behavioural traits such as low education, smoking, poor diet, neglect of oral health, lack of exercise, and hypertension are few of the risk factors that are shared commonly amongst these conditions. In addition, common genetic susceptibility traits such as the apolipoprotein ɛ gene, together with an individual’s life style can also influence the development of co-morbidities such as periodontitis, atherosclerosis/stroke, diabetes, and Alzheimer’s disease. This review specifically addresses the susceptibility of apolipoprotein ε gene allele 4 as the plausible commonality for the etiology of co-morbidities that eventually result from periodontal diseases and ultimately progress to dementia.

Repository Staff Only: item control page