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Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI)

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Tong, H.-J., Fitzgerald, C., Gallimore, P. J., Kalberer, M., Kuimova, M. K., Seville, P. C. ORCID: 0000-0001-8546-3474, Ward, A. D. and Pope, F. D. (2014) Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI). Chemical Communications, 50 (98). pp. 15499-15502. ISSN 1359-7345

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Official URL: http://dx.doi.org/10.1039/C4CC05803H

Abstract

Individual micron-sized solid particles from a Salamols pharmaceutical inhaler are stably captured in air using an optical trap for the first time. Raman spectroscopy of the levitated particles allows online interrogation of composition and deliquescent phase change within a high humidity environment that mimics the particle’s travel from inhaler to lung

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