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Drug-loaded liposome-capped mesoporous core-shell magnetic nanoparticles for cellular toxicity study

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Sharifabad, Maneea Eizadi, Mercer, Tim ORCID: 0000-0002-1557-2138 and Sen, Tapas ORCID: 0000-0002-0463-7485 (2016) Drug-loaded liposome-capped mesoporous core-shell magnetic nanoparticles for cellular toxicity study. Nanomedicine, 11 (21). pp. 2757-2767. ISSN 1743-5889

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Official URL: http://doi.org/10.2217/nnm-2016-0248

Abstract

Liposome-capped core-shell mesoporous silica-coated superparamagnetic iron oxide nanoparticles called 'magnetic protocells' were prepared as novel nanocomposites and used for loading anticancer drug doxorubicin (DOX) for cellular toxicity study. Cytotoxicity of the magnetic protocells with or without DOX was tested in vitro on commercial MCF7 and U87 cell lines under alternating magnetic field MCF7 cell line treated with the DOX-loaded nanoparticles under alternating magnetic field exhibited nearly 20% lower survival rate...

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