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Sherer, Christopher 
ORCID: 0000-0002-6422-9870, Tolaymat, Ibrahim, Rowther, Farzana, Warr, Tracy and Snape, Timothy James ORCID: 0000-0003-2766-4491
(2017)
Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells.
Bioorganic & Medicinal Chemistry Letters, 27
(7).
pp. 1561-1565.
ISSN 0960-894X
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Official URL: http://dx.doi.org/10.1016/j.bmcl.2017.02.033
Abstract
The prognosis for glioblastoma patients is, at best, poor, with the median time of survival after diagnosis measured in months. As such, there is much need for the rapid development of potent and novel treatments. Herein, we report our preliminary findings on the SAR of a series of indole-3-carbinol and related fragments and reveal a potent lead with low micromolar activity against a particularly resistant glioblastoma cell culture, providing a new platform for future development of a new therapy in this area.
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