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Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples

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Hands, James R., Dorling, Konrad M., Abel, Peter ORCID: 0000-0002-5221-7653, Ashton, Katherine M., Brodbelt, Andrew, Davis, Charles, Dawson, Timothy, Jenkinson, Michael D., Lea, Robert W. et al (2014) Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples. Journal of Biophotonics, 7 (3-4). pp. 189-199. ISSN 1864-063X

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Official URL: https://doi.org/10.1002/jbio.201300149

Abstract

Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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