Systematic Review and Meta-Analysis of Psychosocial Risk Factors for Stroke

Lightbody, Catherine Elizabeth orcid iconORCID: 0000-0001-5016-3471, Clegg, Andrew orcid iconORCID: 0000-0001-8938-7819, Patel, Kulsum, Cook Lucas, Julie orcid iconORCID: 0000-0002-6391-5430, Storey, Hannah orcid iconORCID: 0000-0002-1250-8368, Hackett, Maree orcid iconORCID: 0000-0003-1211-9087 and Watkins, Caroline Leigh orcid iconORCID: 0000-0002-9403-3772 (2017) Systematic Review and Meta-Analysis of Psychosocial Risk Factors for Stroke. Seminars in Neurology, 37 (03). pp. 294-306. ISSN 0271-8235

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Several studies have assessed the link between psychosocial risk factors and stroke; however, the results are inconsistent. We have conducted a systemic review and meta-analysis of cohort or case-control studies to ascertain the association between psychosocial risk factors (psychological, vocational, behavioral, interpersonal and neuropsychological) and the risk of stroke.

Systematic searches were undertaken in MEDLINE, EMBASE, CINAHL, PsycInfo and the Cochrane Database of Systematic Reviews between 2000 and January 2017. Two reviewers independently screened titles, abstracts and full texts. One reviewer assessed quality and extracted data, which was checked by a second reviewer. For studies that reported risk estimates, a meta-analysis was performed.

We identified 41 cohort studies and five case-control studies. No neuropsychological papers were found. Overall pooled adjusted estimates showed that all other psychosocial risk factors were independent risk factors for stroke. Psychological factors increased the risk of stroke by 39% (HR 1.39 95% CI:1.27;1.51), vocational by 35% (HR 1.35 95% CI: 1.20;1.51), and interpersonal by 16% (HR 1.16 95% CI:1.03;1.31). and the effects of behavioral factors were equivocal (HR 0.94 95% CI: 0.20;4.31). The meta-analyses were affected by heterogeneity.

Psychosocial risk factors are associated with an increased risk of stroke

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