Development of nanosponges from erythrocyte ghosts for removal of streptolysin-O and α haemolysin from mammalian blood

Abstract

Bacteria can cause many different types of infections. Virulence factors e.g. adherence proteins, biofilm formation, endotoxins and exotoxins allow invasion by bacteria and cause infections such as respiratory, urinary, and intestinal and blood stream infections. If left untreated they can lead to a condition known as sepsis. Sepsis is a whole body inflammatory response that can be fatal. The aim of this study is to develop biomimetic nanosponges from mammalian erythrocyte ghosts, as a potential treatment for toxin related sepsis.