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Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

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Wang, Xiaoling, Tabudravu, Jioji ORCID: 0000-0002-6930-6572, Rateb, Mostafa Ezzat, Annand, Krystal Joan, Qin, Zhiwei, Jaspars, Marcel, Deng, Zixin, Yu, Yi and Deng, Hai (2013) Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus. Molecular BioSystems, 9 (6). pp. 1286-1289. ISSN 1742-206X

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Official URL: https://doi.org/10.1039/C3MB70081J

Abstract

The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2–3, respectively.

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