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Tabudravu, Jioji 
ORCID: 0000-0002-6930-6572, Eijsink, V.G.H, Gooday, G.W, Jaspars, M, Komander, D, Legg, M, Synstad, B and van Aalten, D.M.F
(2002)
Psammaplin A, a chitinase inhibitor isolated from the fijian marine sponge Aplysinella rhax.
Bioorganic & Medicinal Chemistry, 10
(4).
pp. 1123-1128.
ISSN 0968-0896
Full text not available from this repository.
Official URL: https://doi.org/10.1016/S0968-0896(01)00372-8
Abstract
Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.
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