Medication-related osteonecrosis of the jaw - a current review

Domah, Farya, Shah, N., Domah, J. and Shah, Raunaq Pravinchandra (2018) Medication-related osteonecrosis of the jaw - a current review. Oral Surgery, 11 (3). pp. 250-258. ISSN 1752-2471

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This study was aimed to discuss different classes of antiresorptive agents and their modes of action, to review the proposed mechanisms in the pathophysiology of osteonecrosis development and to analyse the prevention and the management of medication-related osteonecrosis of the jaw.

Materials and methods
Three databases were searched for relevant articles: PubMed, Ovid and Dentistry and Oral Sciences Source. Current literature consists mainly of case series, case reports and expert body opinions.

The repertoire of antiresorptive medication keeps expanding as novel drugs are being introduced. The exact pathway that leads to the development of osteonecrosis remains to be elucidated, but different mechanisms have been put forward. An attempt at staging has been made, and treatment guidelines have been drawn but opinions remain divided. New treatments are being trialled; however, evidence is lacking.

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