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Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat

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Al Kury, L., Smail, M., Qureshi, M.A., Sydorenko, V., Shmygol, A., Oz, M., Singh, Jaipaul ORCID: 0000-0002-3200-3949 and Howarth, F.C. (2018) Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat. Journal of Diabetes Research, 2018 . ISSN 2314-6745

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Official URL: https://doi.org/10.1155/2018/2974304

Abstract

The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients’ age and duration of diabetes. The
cellular basis of hemodynamic dysfunction in type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used non-obese, non-hypertensive genetic model of T2DM which is characterized by
insulin resistance, elevated blood glucose, alterations in blood lipid profile and cardiac dysfunction.

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