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Shortening and calcium transport in epicardial and endocardial ventricular myocytes from the streptozotocin-induced diabetic rat

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Howarth, F C, Al Kury, L, Sydorenko, V, Smail, MMA, Qureshi, M A, Shmygol, A, Oz, M and Singh, Jaipaul ORCID: 0000-0002-3200-3949 (2018) Shortening and calcium transport in epicardial and endocardial ventricular myocytes from the streptozotocin-induced diabetic rat. Cardiovascular Research, 114 (S1). S20-S20. ISSN 0008-6363

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Official URL: https://doi.org/10.1093/cvr/cvy060.039

Abstract

Background/Introduction: Diabetes mellitus (DM) is a serious global health problem. According to the International Diabetes Federation Atlas 2015 the estimated number of people with DM worldwide is expected to increase from 415 million in 2015 to 642 million in 2040. Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. Electromechanical function is frequently compromised in the diabetic heart.

Purpose: To investigate the regional effects of DM on shortening and calcium (Ca2+) transport in epicardial (EPI) and endocardial (ENDO) myocytes from the left ventricle of streptozotocin (STZ) - induced...

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