Cognitive Behavior Therapy, Exercise, or Both for Treating Chronic Widespread Pain

McBeth, John, Prescott, Gordon orcid iconORCID: 0000-0002-9156-2361, Scotland, Graham, Lovell, Karina, Keeley, Philip, Hannaford, Phil, McNamee, Paul, Symmons, Deborah P. M., Woby, Steve et al (2012) Cognitive Behavior Therapy, Exercise, or Both for Treating Chronic Widespread Pain. JAMA Internal Medicine, 172 (1). pp. 48-57. ISSN 2168-6106

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Official URL: https://doi.org/10.1001/archinternmed.2011.555

Abstract

Background The clinical impact of telephone-delivered cognitive behavioral therapy (TCBT), exercise, or a combined intervention in primary care patients with chronic widespread pain (CWP) is unclear.

Methods A total of 442 patients with CWP (meeting the American College of Rheumatology criteria) were randomized to receive 6 months of TCBT, graded exercise, combined intervention, or treatment as usual (TAU). The primary outcome, using a 7-point patient global assessment scale of change in health since trial enrollment (range: very much worse to very much better), was assessed at baseline and 6 months (intervention end) and 9 months after randomization. A positive outcome was defined as “much better” or “very much better.” Data were analyzed using logistic regression according to the intention-to-treat principle.

Results The percentages reporting a positive outcome at 6 and 9 months, respectively, were TAU group, 8% and 8%; TCBT group, 30% and 33%; exercise group, 35% and 24%; and combined intervention group, 37% and 37% (P < .001). After adjustment for age, sex, center, and baseline predictors of outcome, active interventions improved outcome compared with TAU: TCBT (6 months: odds ratio [OR], 5.0 [95% CI, 2.0-12.5]; 9 months: OR, 5.4 [95% CI, 2.3-12.8]), exercise (6 months: OR, 6.1 [95% CI, 2.5-15.1]; 9 months: OR, 3.6 [95% CI, 1.5-8.5]), and combined intervention (6 months: OR, 7.1 [95% CI, 2.9-17.2]; 9 months: OR, 6.2 [95% CI, 2.7-14.4]). At 6 and 9 months, combined intervention was associated with improvements in the 36-Item Short Form Health Questionnaire physical component score and a reduction in passive coping strategies. Conclusions on cost-effectiveness were sensitive to missing data.

Conclusion TCBT was associated with substantial, statistically significant, and sustained improvements in patient global assessment.


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