Enhanced anti-psoriatic efficacy and regulation of oxidative stress of a novel topical babchi oil (Psoralea corylifolia) cyclodextrin-based nanogel in a mouse tail model

Abstract

Psoriasis is a proliferative inflammatory skin disorder with relapsing episodes. Herein, the efficacy of babchi oil (BO) loaded nanostructure gel was evaluated for antipsoriatic activity and oxidative stress biomarkers assessment using mouse tail model. BO was entrapped into cyclodextrin-based nanocarriers (360.9 ± 19.55 nm), followed by incorporation into a Carbopol gel and characterized for viscosity, spreadability and texture analysis. The gels were topically applied on mouse-tails once daily for fourteen days. Evaluation of antipsoriatic activity as determined by histopahological observations of orthokeratotic epidermis revealed two times higher efficacy of BO nanogel than the native BO gel. Further, significantly enhanced superoxide dismutase (SOD) and reduced glutathione (GSH) levels and diminished malondialdehyde (MDA) and nitrite (NO) levels revealed that nanogels played a major role in management of ROS associated in psoriasis pathogenesis. Hence, this study provides strong evidence for use cyclodextrin-based nanogels as safe and better delivery carrier of BO for management of psoriasis.