Synthesis, characterisation and bioconjugation of [109Cd]CdSe/ZnS core/shell quantum dots as “proof of principle” for the potential development of an anti-cancer theranostic

Gillies, James Millar orcid iconORCID: 0000-0002-9956-509X (2019) Synthesis, characterisation and bioconjugation of [109Cd]CdSe/ZnS core/shell quantum dots as “proof of principle” for the potential development of an anti-cancer theranostic. Inorganica Chimica Acta, 495 . p. 119001. ISSN 0020-1693

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Official URL: http://dx.doi.org/10.1016/j.ica.2019.119001

Abstract

This work describes the synthesis and analysis of radioactive multifunctional nanoparticle probes based on CdSe/ZnS semiconductor quantum dots (QDs) for potential in vitro and in vivo anti-cancer theranostics. The synthetic design involved the radiosynthesis of luminescent CdSe/ZnS QDs using the SPECT imaging agent Cd-109 as the cadmium elemental source. These radioactive nanoparticle materials were then rendered water dispersed and bioconjugated to the tumor-targeting ligand Rituximab.


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