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1,8-Substituted anthraquinones, anthrones and bianthrones as potential non-azole leads against fungal infections

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Jalab, Murhaf, Critchley, Megan, Taylor, Charlotte May, Lawrence, Clare Louise ORCID: 0000-0003-0170-0079 and Smith, Robert B ORCID: 0000-0002-2829-5360 (2019) 1,8-Substituted anthraquinones, anthrones and bianthrones as potential non-azole leads against fungal infections. Bioorganic chemistry, 91 . p. 103151. ISSN 0045-2068

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Official URL: https://doi.org/10.1016/j.bioorg.2019.103151

Abstract

The synthesis of a variety of 1,8-substituted anthraquinones, anthrones and bianthrones and their potential as antifungal agents is evaluated. Preliminary screening against Schizosaccharomyces pombe (S. pombe), a fission yeast, and Saccharomyces cerevisiae (S. cerevisiae), a budding yeast, is reported. Both these yeast species demonstrate close homologue to a number of pathogenic fungi. [Abstract copyright: Copyright © 2019. Published by Elsevier Inc.]

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