Jalab, Murhaf, Critchley, Megan, Taylor, Charlotte May, Lawrence, Clare Louise ORCID: 0000-0003-0170-0079 and Smith, Robert B
ORCID: 0000-0002-2829-5360
(2019)
1,8-Substituted anthraquinones, anthrones and bianthrones as potential non-azole leads against fungal infections.
Bioorganic chemistry, 91
.
p. 103151.
ISSN 0045-2068
Preview |
PDF (Author Accepted Manuscript)
- Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. 466kB |
Official URL: https://doi.org/10.1016/j.bioorg.2019.103151
Abstract
The synthesis of a variety of 1,8-substituted anthraquinones, anthrones and bianthrones and their potential as antifungal agents is evaluated. Preliminary screening against Schizosaccharomyces pombe (S. pombe), a fission yeast, and Saccharomyces cerevisiae (S. cerevisiae), a budding yeast, is reported. Both these yeast species demonstrate close homologue to a number of pathogenic fungi. [Abstract copyright: Copyright © 2019. Published by Elsevier Inc.]
Repository Staff Only: item control page