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Investigation of PARP1 as a Therapeutic Target for Glioblastoma

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Panchal, Krishna (2019) Investigation of PARP1 as a Therapeutic Target for Glioblastoma. Masters thesis, University of Central Lancashire.

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Abstract

This study investigated whether PARP1 could be a therapeutic target for GBM, measuring the effects of PARP1 inhibition by olaparib, alone and in combination with temozolomide and cisplatin on cell viability, proliferation, cell cycle arrest, apoptosis and autophagy in U87-MG grade IV glioblastoma and SVG p12 foetal glia cell lines cultured under normoxic (21% O2) and hypoxic (1% O2) conditions.

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