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Liu, Yating, Su, Li, Fang, Qing, Tabudravu, Jioji 
ORCID: 0000-0002-6930-6572, Yang, Xiaohui, Rickaby, Kirstie, Trembleau, Laurent, Kyeremeh, Kwaku, Deng, Zixin et al
(2019)
Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A.
The Journal of organic chemistry, 84
(24).
pp. 16323-16328.
ISSN 0022-3263
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Official URL: https://doi.org/10.1021/acs.joc.9b02688
Abstract
Tricyclic carbazole is an important scaffold in many naturally occurring metabolites, as well as valuable building blocks. Here we report the reconstitution of the ring A formation of the bacterial neocarazostatin A carbazole metabolite. We provide evidence of the involvement of two unusual aromatic polyketide proteins. This finding suggests how new enzymatic activities can be recruited to specific pathways to expand biosynthetic capacities. Finally, we leveraged our bioinformatics survey to identify the untapped capacity of carbazole biosynthesis.
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