Phages Enter the Fight against Colorectal Cancer

Kannen, Vinicius, Parry, Lee and Martin, Francis L orcid iconORCID: 0000-0001-8562-4944 (2019) Phages Enter the Fight against Colorectal Cancer. Trends in Cancer, 5 (10). pp. 577-579.

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Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC. [Abstract copyright: Copyright © 2019 Elsevier Inc. All rights reserved.]

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