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Fluorescein-entrapped magnetosomes for magnetically assisted photodynamic therapy

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Parul, Sen, Tapas orcid iconORCID: 0000-0002-0463-7485 and Roy, Indrajit (2021) Fluorescein-entrapped magnetosomes for magnetically assisted photodynamic therapy. Nanomedicine, 16 (11). pp. 883-894. ISSN 1743-5889

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Official URL: https://doi.org/10.2217/nnm-2020-0445

Abstract

Aim: We investigated the application of fluorescein (FL)-entrapped magnetosomes, in other words, silica-coated iron oxide nanoparticles entrapped within niosomes (SIO/NIO), in magnetically assisted photodynamic therapy (PDT) in vitro. Methods: Panc-1 cells were treated with the magnetosomes, with and without external magnetic guidance, and irradiated with blue light. Results & conclusion: Upon photoactivation, the FL-entrapped magnetosomes can produce higher singlet oxygen in comparison to FL-entrapped micelles, probably due to the higher release tendency of the photosensitizer from the former. In vitro studies in Panc-1 cells revealed magnetically assisted enhancement in the cellular uptake of the magnetosomes. Magnetic assistance also led to enhancement in PDT efficiency in cells treated with the FL-entrapped magnetosomes and light, thus highlighting their potential in PDT.


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