The viral capsid as novel nanomaterials for drug delivery

Aljabali, Alaa AA, Hassan, Sk Sarif, Pabari, Ritesh M, Shahcheraghi, Seyed H, Mishra, Vijay, Charbe, Nitin B, Chellappan, Dinesh K, Dureja, Harish, Gupta, Gaurav et al (2021) The viral capsid as novel nanomaterials for drug delivery. Future Science OA, 7 (9).

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The purpose of this review is to highlight recent scientific developments and provide an overview of virus self-assembly and viral particle dynamics. Viruses are organized supramolecular structures with distinct yet related features and functions. Plant viruses are extensively used in biotechnology, and virus-like particulate matter is generated by genetic modification. Both provide a material-based means for selective distribution and delivery of drug molecules. Through surface engineering of their capsids, virus-derived nanomaterials facilitate various potential applications for selective drug delivery. Viruses have significant implications in chemotherapy, gene transfer, vaccine production, immunotherapy and molecular imaging.

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