Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture

Maglangit, Fleurdeliz, Wang, Shan, Moser, Arvin, Kyeremeh, Kwaku, Trembleau, Laurent, Zhou, Yongjun, Clark, David James, Tabudravu, Jioji orcid iconORCID: 0000-0002-6930-6572 and Deng, Hai (2024) Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture. Journal of Natural Products . ISSN 0163-3864

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Official URL: https://doi.org/10.1021/acs.jnatprod.3c01012

Abstract

Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 + 5] spiro chemical architectures, were isolated from Streptomyces sp. MA37 ΔaccJ mutant strain. Compounds 1-2 exhibit excellent activity against Gram-positive bacteria (MIC = 1.5–6.3 μg/mL). Notably, 1 and 2 have superior activity against clinically isolated Enterococcus faecium K60–39 (MIC = 4.0 μg/mL and 4.7 μg/mL, respectively) than ampicillin (MIC = 25 μg/mL).


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