Omega-3 Fatty Acids Mitigating Isotretinoin-Induced Cheilitis

Siripanich, Chawalpat orcid iconORCID: 0009-0006-7848-8669, Chow, Yan-Ching orcid iconORCID: 0009-0007-4891-8231 and Ali, Faisal R (2024) Omega-3 Fatty Acids Mitigating Isotretinoin-Induced Cheilitis. Clinical and Experimental Dermatology . ISSN 0307-6938

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Whilst isotretinoin is an effective treatment for severe acne vulgaris, isotretinoin induced cheilitis is one of the most troubling side effects of the treatment. In their excellent review, which briefly covers the treatments for isotretinoin induced cheilitis, Narayaran et al have overlooked the utility of Omega-3 Fatty Acids (O3FA). O3FA, a cluster of long-chain and very-long-chain polyunsaturated fatty acids that the human body cannot synthesise intrinsically, have demonstrated efficacy in improving specific conditions characterised by inflammation, dryness, and moisture loss.

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