Case Report: An Extremely Rare Cause of Locally Recurrent Adenocarcinoma of the Spleen with Unknown Primary

Abstract

The incidence of splenic tumour is relatively low compared to other organs. They are sometimes discovered incidentally on imaging. The majority of primary splenic tumours are diagnosed as benign. Primary malignant tumour of the spleen most commonly involves lymphosarcoma, reticulosarcoma, angiosarcoma and fibrosarcoma [1, 4]. The diagnostic algorithm to determine the nature of the splenic tumour should include series of laboratory tests, imaging studies, positron emission tomography (PET) scans as well as sometimes warranting the need for splenectomy followed by immunohistochemistry profiling. While the occurrence of primary splenic adenocarcinoma is rare, this case study reports recurrent primary splenic tumour with poorly differentiated adenocarcinoma in a patient who initially presented and investigated for anaemia of unknown cause. As to the best of our knowledge, this case has not been reported before and hence the present study provides insight into the response for standard treatment for locally recurrent adenocarcinoma of the spleen with unknown primary.