Comparative Efficacy and Safety of Endoscopic Modalities for Colorectal Cancer Screening in Inflammatory Bowel Disease: A Systematic Review and Network Meta-Analysis

Abstract

Background
Long-standing inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is associated with an increased risk of colorectal cancer (CRC).(1,2) As a result, regular and effective endoscopic surveillance is critical for early detection of dysplasia and prevention of CRC development in IBD patients. Various endoscopic modalities, such as high-definition (HD) white-light endoscopy (WLE), dye-based chromoendoscopy (DCE), and virtual chromoendoscopy (VCE), have been developed and tested to enhance dysplasia detection.(3) However, the relative effectiveness and safety of these techniques remain uncertain, especially in the era of high-definition imaging. This systematic review and network meta-analysis (NMA) will compare the efficacy and safety of different endoscopic modalities for colorectal cancer screening in IBD patients.
Objectives
• To evaluate the comparative efficacy of different endoscopic modalities in detecting dysplasia in patients with IBD.
• To assess the safety profiles of these modalities, with a focus on serious adverse events.