Protocol for Systematic Review and Meta-Analysis Protocol for Bowel Preparation Regimens in Inflammatory Bowel Disease Patients Undergoing Surveillance Colonoscopy

Abstract

Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic condition associated with an increased risk of colorectal cancer (CRC) and dysplasia. [1–3] Surveillance colonoscopies are recommended by international guidelines to detect precancerous changes, with intervals based on disease characteristics and risk factors.[4,5] Achieving adequate bowel preparation is critical to colonoscopy quality, ensuring effective detection of dysplasia and reducing the incidence of post-colonoscopy colorectal cancer (PCCRC).[6–8]However, bowel preparation is often a source of significant patient burden, particularly in IBD patients who require frequent procedures over their lifetime.
Several bowel preparation regimens are available, and current guidelines recommend polyethylene glycol (PEG)-based preparations for IBD patients. [9] However, the optimal regimen in this special population remains unclear. This systematic review and meta-analysis aim to evaluate the efficacy and safety of different bowel preparation regimens for IBD patients undergoing surveillance colonoscopy, providing evidence to guide clinical practice and future guidelines.
2. Objectives
The primary objective of this review is to assess the quality of bowel preparation regimens in IBD patients undergoing colonoscopy. Secondary objectives include evaluating patient acceptability, tolerability, polyp detection rates, and safety outcomes.