Surface engineering of nanoparticles in suspension for particle based bio-sensing

Sen, Tapas orcid iconORCID: 0000-0002-0463-7485 and Bruce, Ian J. (2012) Surface engineering of nanoparticles in suspension for particle based bio-sensing. Scientific Reports, 2 (564). pp. 1-6. ISSN 2045-2322

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Surface activation of nanoparticles in suspension using amino organosilane has been carried out via strict
control of a particle surface ad-layer of water using a simple but efficient protocol ‘Tri-phasic Reverse
Emulsion’ (TPRE). This approach produced thin and ordered layers of particle surface functional groups
which allowed the efficient conjugation of biomolecules. When used in bio-sensing applications, the
resultant conjugates were highly efficient in the hybrid capture of complementary oligonucleotides and the detection of food borne microorganism. TPRE overcomes a number of fundamental problems associated with the surface modification of particles in aqueous suspension viz. particle aggregation, density and organization of resultant surface functional groups by controlling surface condensation of the aminosilane. The approach has potential for application in areas as diverse as nanomedicine, to food technology and industrial catalysis.

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