Lists
Lists
Maher, E.R., Bentley, E., Yates, J.R.W., Barton, D., Jennings, A., Fellows, I.W., Ponder, M.A., Ponder, B.A.J., Benjamin, Caroline et al (1990) Mapping of Von Hippel-Lindau disease to chromosome 3p confirmed by genetic linkage analysis. Journal of the Neurological Sciences, 100 (1-2). pp. 27-30. ISSN 0022510X
![[thumbnail of Publisher's post-print for classroom teaching and internal training purposes at UCLan.]](https://clok.uclan.ac.uk/style/images/fileicons/application_pdf.png) |
PDF (Publisher's post-print for classroom teaching and internal training purposes at UCLan.)
- Published Version
Restricted to Registered users only 315kB |
Official URL: http://dx.doi.org/10.1016/0022-510X(90)90008-B
Abstract
Genetic linkage studies were performed in 12 British families with von Hippel-Lindau disease (VHL) using RFLPs at three loci (DNF15S2, THRB, RAF1) on the short arm of chromosome 3. Linkage was detected between the VHL disease locus and RAF1 with a maximum lod score of 3.88 at a recombination fraction of 0.05 (confidence interval 0.003-0.18). Multipoint linkage analysis suggested that the most likely location for the VHL disease locus is telomeric to THRB. These results confirm earlier reports localizing the VHL gene to the short arm of chromosome 3, and provide no evidence for genetic heterogeneity.
Repository Staff Only: item control page
