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Promising near-infrared non-targeted probes: benzothiazole heptamethine cyanine dyes

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Okoh, Okoh Adeyi, Bisby, Roger H., Lawrence, Clare Louise ORCID: 0000-0003-0170-0079, Rolph, Carole E. and Smith, Robert B. (2013) Promising near-infrared non-targeted probes: benzothiazole heptamethine cyanine dyes. Journal of Sulfur Chemistry . pp. 1-15. ISSN 1741-5993

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Official URL: http://dx.doi.org/10.1080/17415993.2013.778258

Abstract

A series of benzothiazole heptamethine cyanine dyes have been synthesized and their photophysical properties evaluated in relation to their structural features. These have been compared against two classical probes of this type: Indocyanine Green (IGC) and New Indocyanine Green (IR-820). Growth inhibitory studies were also performed using a eukaryotic, unicellular organism, fission yeast Schizosaccharomyces pombe. Herein we highlight some potentially interesting candidates with improved fluorescence quantum yields when compared with ICG and IR-820.

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