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Porphyromonas gingivalis-lipopolysaccharide and amyloid-β: A dangerous liaison for impairing memory?

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Singhrao, Sim (2025) Porphyromonas gingivalis-lipopolysaccharide and amyloid-β: A dangerous liaison for impairing memory? Journal of Alzheimer's Disease . ISSN 1387-2877

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Official URL: https://doi.org/10.1177/13872877251343317

Abstract

Alzheimer's disease is characterized by declining memory and the presence of insoluble amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. Gui et al.1 studied the effects of low levels of Porphyromonas gingivalis-lipopolysaccharide (P. gingivalis-LPS) and soluble Aβ on synaptic proteins, synapsin1 (SYN1) and post-synaptic density protein-95 (PSD-95). Their study revealed increased proinflammatory cytokine production in microglial cells (MG6) treated with P. gingivalis-LPS and Aβ, while neuronal cells, N2a, exposed to MG6-conditioned medium showed SYN1 and PSD-95 loss. This suggests that excessive neuroinflammation may contribute to synaptic protein and memory loss, offering mechanistic insights into P. gingivalis-LPS-mediated inflammatory pathways in periodontitis.

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